The field of peptide research continues to advance rapidly, with recent publications highlighting innovations in synthesis, computational design, biomaterial integration, and the discovery of novel bioactive peptide architectures. The following list summarizes key findings and discussions from the past 60 days that are particularly relevant to laboratory researchers.
This review provides an overview of technological advances enabling programmable peptide engineering across discovery-to-development pipelines, discussing innovations in automated flow synthesis, chemoselective ligation, and computational tools for expanding accessible peptide chemical and functional space.
Recent advances in multimodal foundation models are accelerating peptide screening and optimization for applications in smart biomaterials and functional tissue engineering, where peptides function as receptor ligands, antimicrobial agents, and material-functionalization modules in hydrogels and scaffolds.
A large-scale structural survey of predicted toxin-like peptide scaffolds across beetles revealed a broader repertoire of structurally constrained bioactive peptides, establishing a structural atlas for understanding their evolutionary diversity and biotechnological potential.
This review encapsulates essential physicochemical factors and chemical modification strategies influencing the properties and biological activity of cyclic peptides, which are a diverse class of bioactive compounds with significant therapeutic potential.
Researchers identified ATP13A3 as a direct target for negative control by antizyme, demonstrating that antizyme binding at nanomolar affinity suppresses polyamine ATPase activity and impacts polyamine uptake in human neuroblastoma cells.
This perspective provides an overview of the current peptide manufacturing landscape and highlights promising technological advancements in solid-phase peptide synthesis (SPPS) and alternative methods to improve efficiency and scalability while reducing environmental impact.
A surface biofunctionalization strategy using rationally designed peptides conferred antifouling and regenerative properties to implantable polymeric scaffolds in vitro, demonstrating significant reduction in bacterial adhesion and enhanced mammalian cell attachment.
Researchers demonstrated rapid, UV-activated stabilization of a collagen mimetic peptide triple helix via thiomaleimide self-crosslinking, with control over light dose enabling precise in situ control and stabilization of peptide assemblies.
A peptide mimetic platform was developed to profile mycobacterial L,D-transpeptidases, elucidating the substrate scope and tolerance of these enzymes across different Ldt paralogs, which are involved in bacterial cell wall synthesis.
Links go to the original sources. Listing a study is not an endorsement, and nothing here describes use in humans.